Purity profiling of Peptide Drugs

Suggested Standards of Purity for Foods and Drugs

Distinct profiling of antimicrobial peptide families

MOTIVATION The increased prevalence of multi-drug resistant (MDR) pathogens heightens the need to design new antimicrobial agents. Antimicrobial peptides (AMPs) exhibit broad-spectrum potent activity against MDR pathogens and kills rapidly, thus giving rise to AMPs being recognized as a potential substitute for conventional antibiotics. Designing new AMPs using current in-silico approaches is, ...

Phenotypic profiling identifies novel anticancer drugs.

Image analysis of vasculature in a tumor-derived 3D matrix shows high predictive value in discovering angiogenesis inhibitors.

the necessity of determining purity levels of drugs in judging drug abuse cases

one of the vague issues in relation to cases involving drug abuse is the necessity of determining the purity of drugs. gaps in related laws have created confusion for judges. some believe purity levels of drugs used by criminals must be considered in the processing of their cases as well as in their punishment. since the harsh processing sometimes involves death and life, the controversy is esp...

Peptidase Substrates via Global Peptide Profiling

Peptide metabolism is a complex process that involves many proteins working in concert. Mass spectrometry-based global peptide profiling of mice lacking dipeptidyl peptidase 4 (DPP4) identified endogenous DPP4 substrates and revealed an unrecognized pathway during proline peptide catabolism that interlinks aminopeptidase and DPP4 activities. Together, these studies elucidate specific aspects of...